CaseReportA70-year-oldmalewaspresentedtoouroutpatientclinicwithasymptomaticdarkpatchesbilaterallyonmalarregion.(Figure1)Thelesionhadslowlyenlargedovertwoyearsandphysicalexaminationrevealedyellowtoskincolored,softmovablecysticmasses,rangingfrom10mmto20mminsizewithnopunctum.Therewasnoremarkablefamilyhistoryofsimilarlesionsandthepatienthadnoothercutaneousdiseases.Thenails,teethandhairwereallnormal.Routinelaboratoryinvestigationswerewithinnormallimits.患者，男，70岁。因双侧颧区出现暗斑，无临床症状（图1）来院就诊。2年来，病灶逐渐扩大，体检发现病灶发黄到接近肤色，囊性肿块，质软，可移动，大小10mm-20mm，无凹陷。患者无类似疾病家族史，无其他皮肤病。指甲、牙齿和头发均处于正常状态。常规实验室检查结果均正常。

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Surgicalexcisionwasdoneunderlocalanesthesia.(Figure2)Thelesionwassentforhistopathologicalexamination.(Figure3A-B)ThespecimenwasstainedinHematoxylinandEosinandwasseenunderx,thehistopathologyslideshowedmildhyperkeratosis.Multiplecystswerelinedbystratifiedsquamousepitheliumandgranularlayerswereseen.Thelumenofthecystswasfilledwithlaminatedkeratinandafewofthecystsshowedfocalulceration.Adjacenttissueexhibitedskinappendages,denseacuteandchronicinflammatorycellsandnumerousforeignbodygiantcells.Afewmelanophageswerealsoseenindermis.Therewasnoevidenceofgranulomaormalignancy.(Figure4)行局麻切除。（图2）病灶送至组织病理学检查。（图3A-B）样本经苏木精和伊红染色后在x镜下观察，组织病理切片显示轻度角化过度。多个囊肿衬以复层鳞状上皮，可观察到颗粒层。囊肿内腔充满叠层角蛋白，一些囊肿出现局灶性溃疡。邻近组织显示皮肤附件、急慢性炎症细胞和大量异物巨细胞。真皮层观察到少量噬黑素细胞。无证据表明肉芽肿或恶性肿瘤。（图4）

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DiscussionSteatocystomamultiplexisanun